The mucinous ovarian cancer: classification and clinical use of cancer biomarkers for diagnosis


Article info

2018-07-01
2018-08-29
55 - 58

Keywords

  • serology
  • Ca125
  • screening
  • Mucinous ovarian cancer (MOC)
  • Women
  • Jordan
  • CEA

Abstract

The aims of the study were to examine the prevalence of positive mucinous ovarian carcinoma (MOC) at different stages as well as to investigate the age at diagnosis and histological type, and to assess the correlation between the carcinoembryonic antigen/ cancer antigen 125 (CEA/CA 125) tests and the diagnosis of ovarian cancers retrospectively, to promote the prognosis and patient’s health outcome. Descriptive a cross-sectional correlational design was used to examine the prevalence of positive ovarian cancer over a period of seven years of follow-up between 2010 and 2016. All study analysis was performed using SPSS version 22. P<0.05 was taken to indicate a statistically significant value. We found that about 70% of cases showed elevation of CEA marker and about 95% of them showed elevation of Ca125. The age-specific incidence rate increased greatly in women aged 50 years or older. The majority of the patients had stage III or IV disease. Our study results can be used as a detection method of possible new ovarian cancer cases in an early stage and would provide a quick non-invasive screening method for women with strong risk factors such as old age, smoking, family history, history of other tumors and obesity.

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The mucinous ovarian cancer: classification and clinical use of cancer biomarkers for diagnosis


معلومات المقال

2018-07-01
2018-08-29
55 - 58

الكلمات الإفتتاحية

  • serology
  • Ca125
  • screening
  • Mucinous ovarian cancer (MOC)
  • Women
  • Jordan
  • CEA

الملخص

The aims of the study were to examine the prevalence of positive mucinous ovarian carcinoma (MOC) at different stages as well as to investigate the age at diagnosis and histological type, and to assess the correlation between the carcinoembryonic antigen/ cancer antigen 125 (CEA/CA 125) tests and the diagnosis of ovarian cancers retrospectively, to promote the prognosis and patient’s health outcome. Descriptive a cross-sectional correlational design was used to examine the prevalence of positive ovarian cancer over a period of seven years of follow-up between 2010 and 2016. All study analysis was performed using SPSS version 22. P<0.05 was taken to indicate a statistically significant value. We found that about 70% of cases showed elevation of CEA marker and about 95% of them showed elevation of Ca125. The age-specific incidence rate increased greatly in women aged 50 years or older. The majority of the patients had stage III or IV disease. Our study results can be used as a detection method of possible new ovarian cancer cases in an early stage and would provide a quick non-invasive screening method for women with strong risk factors such as old age, smoking, family history, history of other tumors and obesity.

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