Palestinian Medical and Pharmaceutical Journal (Pal. Med. Pharm. J.)

The effect of sleep extension on metabolic and androgen parameters of healthy women with habitual short sleep duration: Pilot study

Article info

2022-01-14
2023-01-12
337 - 342

Keywords

  • Sleep Curtailment; Insulin Resistance; Androgens
  • Leptin

Abstract

Aims: Sleep curtailment, a common behavior in modern societies, is associated with sig-nificant alterations in metabolic and endocrine profiles. This pilot study aimed to investigate the potential benefits of sleep extension, under real-life conditions, on insulin sensitivity, an-drogens, and leptin, in women with habitual short sleep duration. Methods: In a single-arm study design, healthy pre-menopausal women with ≤ 6 hours of daily sleep (n=10) were in-structed to increase their sleep duration by one hour daily for one month. Fasting blood sam-ples were obtained on days 2-3 of the menstrual cycle, at baseline, and after the intervention. Samples were analyzed for glucose, insulin, leptin, total testosterone, sex hormone-binding globulin, and dehydroepiandrosterone-sulfate. Measurement of sleep duration was based on the participants' subjective reporting using sleep logs, and baseline data were compared to post-intervention. Results: Seven women completed the intervention and significantly in-creased their sleep duration by 40.7 ± 14 min (mean ± standard deviation). However, our pilot data did not indicate significant changes in any of the parameters assessed at the end of the intervention. Conclusion: The impact of sleep extension on various metabolic and androgen parameters in women requires further investigation with larger samples and more controlled designs.

The effect of sleep extension on metabolic and androgen parameters of healthy women with habitual short sleep duration: Pilot study

معلومات المقال

2022-01-14
2023-01-12
337 - 342

الكلمات الإفتتاحية

  • Sleep Curtailment; Insulin Resistance; Androgens
  • Leptin

الملخص

Aims: Sleep curtailment, a common behavior in modern societies, is associated with sig-nificant alterations in metabolic and endocrine profiles. This pilot study aimed to investigate the potential benefits of sleep extension, under real-life conditions, on insulin sensitivity, an-drogens, and leptin, in women with habitual short sleep duration. Methods: In a single-arm study design, healthy pre-menopausal women with ≤ 6 hours of daily sleep (n=10) were in-structed to increase their sleep duration by one hour daily for one month. Fasting blood sam-ples were obtained on days 2-3 of the menstrual cycle, at baseline, and after the intervention. Samples were analyzed for glucose, insulin, leptin, total testosterone, sex hormone-binding globulin, and dehydroepiandrosterone-sulfate. Measurement of sleep duration was based on the participants' subjective reporting using sleep logs, and baseline data were compared to post-intervention. Results: Seven women completed the intervention and significantly in-creased their sleep duration by 40.7 ± 14 min (mean ± standard deviation). However, our pilot data did not indicate significant changes in any of the parameters assessed at the end of the intervention. Conclusion: The impact of sleep extension on various metabolic and androgen parameters in women requires further investigation with larger samples and more controlled designs.

An-Najah National University
Nablus, Palestine
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EIC
Prof. Ismail Warad