Subject Review: Pharmacology and Therapeutics of Anti-sense Oligodeoxynucleotides
Article info
2002-09-18
2003-12-09
2003-12-09
49 - 72
Keywords
Abstract
The purpose of this review is to provide pharmacists and pharmacologists with a background information about current therapeutic potentials and clinical trials on the anti-sense oligonucleotides (AS oligos). Anti-sense oligonucleotides are short, modified single stranded DNA or RNA that hybridize with target mRNA and inhibit synthesis of encoded peptide. This inhibition is achieved by either degradation of target mRNA by RNase enzyme or by blocking translation. The specificity of hybridization makes anti-sense treatment an attractive strategy to selectively modulate the expression of genes involved in the pathogenesis of diseases. Anti-sense oligos have now reached phase I and II in clinical trials for the treatment of cancer and viral infections. One anti-sense drug has been approved for local treatment of retinitis induced by cytomegalovirus. A number of important challenges for the development of anti-sense oligonucleotides in the clinical use have been identified, including stability, cellular uptake, target sequence selection, oligonucleotide: protein interactions, and cost of manufacture.These articles may interest you also
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Subject Review: Pharmacology and Therapeutics of Anti-sense Oligodeoxynucleotides
معلومات المقال
2002-09-18
2003-12-09
2003-12-09
49 - 72
الكلمات الإفتتاحية
الملخص
The purpose of this review is to provide pharmacists and pharmacologists with a background information about current therapeutic potentials and clinical trials on the anti-sense oligonucleotides (AS oligos). Anti-sense oligonucleotides are short, modified single stranded DNA or RNA that hybridize with target mRNA and inhibit synthesis of encoded peptide. This inhibition is achieved by either degradation of target mRNA by RNase enzyme or by blocking translation. The specificity of hybridization makes anti-sense treatment an attractive strategy to selectively modulate the expression of genes involved in the pathogenesis of diseases. Anti-sense oligos have now reached phase I and II in clinical trials for the treatment of cancer and viral infections. One anti-sense drug has been approved for local treatment of retinitis induced by cytomegalovirus. A number of important challenges for the development of anti-sense oligonucleotides in the clinical use have been identified, including stability, cellular uptake, target sequence selection, oligonucleotide: protein interactions, and cost of manufacture.These articles may interest you also
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- الشعور بالوحدة النفسية وعلاقتها بإدمان الانترنت لدى طلبة جامعة أم البواقي في الجزائر
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- تحضير ملونات حساسة لأشعة الليزر وربطها بالعقار المضاد للسرطان "دوكسوروبوسن"
- تأثير خلاصة سبع نباتات تقليدية شائعة الاستعمال على كريات الدم الحمراء
- التقريب الامثل في فضاءات القياس المخروطي
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- المنهج الإعرابي وتحليل الخطاب - المفهوم والإجراء
- دراسة مسحية لفاعلية مضادات حيوية مختلفة لمعالجة عفن الحضنة الأمريكي في الأردن
- السياسة الصليبية البابوية - الإسبانية تجاه الأندلس بعد سقوط القسطنطينية (1453-1492م/857-897هـ)
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