Drug Interactions and Risk of Bleeding among Patients with Atrial Fibrillation (AF) Discharged with Warfarin
Article info
2005-07-25
2006-09-05
2006-09-05
127 - 134
Keywords
Abstract
The objective of this study was to examine and evaluate the frequency of bleeding and serious drug interactions among patients with atrial fibrillation (AF) treated with oral anticoagulant [Warfarin]. A random sample of 59 patients from Al-Watni government hospital in Nablus with a principal or secondary discharge diagnosis of AF was identified. All drug and clinical data were abstracted from the patient's files. We excluded patients who were less than 65 years of age, or left the hospital against medical advice, and those whose AF was transient or could not be confirmed. Of the original 59 AF patients, 19 were cliagnosed who were discharged on Warfarin. The mean age for these patients was 71.7 years. Among the patients discharged on Warfarin, 94.7 % had one or more drug – drug interactions that could lead to increased risk of bleeding. Many patients discharged on Warfarin were having multiple interacting drugs. Patient counseling and follow-up monitoring are essential and should be carried out to minimize the risk of bleeding and other complications.
Sweileh, W., Jaradat, N., Elawee, M., & Al-Shakh, A. (2006). Drug Interactions and Risk of Bleeding among Patients with Atrial Fibrillation (AF) Discharged with Warfarin. An-Najah University Journal for Research - A (Natural Sciences), 20(1), 127–134. https://doi.org/10.35552/anujr.a.20.1.598
[1]W. Sweileh, N. Jaradat, M. Elawee, and A. Al-Shakh, “Drug Interactions and Risk of Bleeding among Patients with Atrial Fibrillation (AF) Discharged with Warfarin,” An-Najah University Journal for Research - A (Natural Sciences), vol. 20, no. 1, pp. 127–134, Sep. 2006, doi: 10.35552/anujr.a.20.1.598.
Sweileh, Waleed, et al. “Drug Interactions and Risk of Bleeding among Patients with Atrial Fibrillation (AF) Discharged with Warfarin.” An-Najah University Journal for Research - A (Natural Sciences), vol. 20, no. 1, Sept. 2006, pp. 127–34. Crossref, https://doi.org/10.35552/anujr.a.20.1.598.
1.Sweileh W, Jaradat N, Elawee M, Al-Shakh A. Drug Interactions and Risk of Bleeding among Patients with Atrial Fibrillation (AF) Discharged with Warfarin. An-Najah University Journal for Research - A (Natural Sciences) [Internet]. 2006 Sep;20(1):127–34. Available from: http://dx.doi.org/10.35552/anujr.a.20.1.598
Sweileh, Waleed, Nidal Jaradat, Moueen Elawee, and Asaad Al-Shakh. “Drug Interactions and Risk of Bleeding among Patients with Atrial Fibrillation (AF) Discharged with Warfarin.” An-Najah University Journal for Research - A (Natural Sciences) 20, no. 1 (September 2006): 127–34. https://doi.org/10.35552/anujr.a.20.1.598.
التداخلات الدوائية وخطر الأصابة بالنزيف عند مرضى atrial fibrillationالذين يستخدمون دواء warfarin
المؤلفون:
معلومات المقال
2005-07-25
2006-09-05
2006-09-05
127 - 134
الكلمات الإفتتاحية
الملخص
الاهداف: اختبار وتقييم احتمالية الإصابة بالنزيف والتداخلات الدوائية عند المرضى المصابين ب atrial fibrillation ويستخدمون المميعات الدموية (warfarin). طريقة البحث: عينة عشوائية مكونة من 59 مريضا"" تم تشخيصهم ب atrial fibrillation في المستشفى الوطني الحكومي – نابلس. وقد تم استخلاص جميع الأدوية والمعلومات السريرية من ملفات المرضى. كما تم استثناء المرضى الذين تقل اعمارهم عن 65 سنة، أو الذين خرجوا من المستشفى خلافا"" لنصيحة الطبيب، أو اولئك الذين كانو يعانون من حالة atrial fibrillation مؤقتة أو لم يتم تأكيدها. النتائج: لقد توصلت الدراسة إلى أنه من أصل 59 مريضا"" مصاباً atrial fibrillation، هناك 19 مريضا"" تم اخراجهم من المستشفى بوصفة warfarin. وكان معدل أعمار هؤلاء المرضى 71.7 سنة. ومن بين المرضى الذين تم صرف دواء warfarin لهم كان 94.7% لديهم تداخلات دوائية (واحد أو أكثر) من هذه التداهلات قد تؤدي الى خطر النزيف. المناقشة والاستنتاج: عدد كبير من المرضى الذين تم صرف دواء warfarin
Sweileh, W., Jaradat, N., Elawee, M., & Al-Shakh, A. (2006). Drug Interactions and Risk of Bleeding among Patients with Atrial Fibrillation (AF) Discharged with Warfarin. An-Najah University Journal for Research - A (Natural Sciences), 20(1), 127–134. https://doi.org/10.35552/anujr.a.20.1.598
[1]W. Sweileh, N. Jaradat, M. Elawee, and A. Al-Shakh, “Drug Interactions and Risk of Bleeding among Patients with Atrial Fibrillation (AF) Discharged with Warfarin,” An-Najah University Journal for Research - A (Natural Sciences), vol. 20, no. 1, pp. 127–134, Sep. 2006, doi: 10.35552/anujr.a.20.1.598.
Sweileh, Waleed, et al. “Drug Interactions and Risk of Bleeding among Patients with Atrial Fibrillation (AF) Discharged with Warfarin.” An-Najah University Journal for Research - A (Natural Sciences), vol. 20, no. 1, Sept. 2006, pp. 127–34. Crossref, https://doi.org/10.35552/anujr.a.20.1.598.
1.Sweileh W, Jaradat N, Elawee M, Al-Shakh A. Drug Interactions and Risk of Bleeding among Patients with Atrial Fibrillation (AF) Discharged with Warfarin. An-Najah University Journal for Research - A (Natural Sciences) [Internet]. 2006 Sep;20(1):127–34. Available from: http://dx.doi.org/10.35552/anujr.a.20.1.598
Sweileh, Waleed, Nidal Jaradat, Moueen Elawee, and Asaad Al-Shakh. “Drug Interactions and Risk of Bleeding among Patients with Atrial Fibrillation (AF) Discharged with Warfarin.” An-Najah University Journal for Research - A (Natural Sciences) 20, no. 1 (September 2006): 127–34. https://doi.org/10.35552/anujr.a.20.1.598.
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