Influence of Corchorus Olitorius (Molokhia) Soup on the In Vivo Absorption of Ciprofloxacin from Immediate Release Tablet in Rabbits
- Asma Radwan
- Naser Shraim
- Josephean Elaraj1
- Malak Jada'a
- Anwar Alheen
- Yasmeen Khanfar
- Nidal Zatar
- Mohamad Abdaldaym3
Article info
2016-05-24
2016-08-23
1 - 6
Keywords
- Corchorus Olitorius
- Food Effect
- Absorption
- Ciprofloxacin
Abstract
This study was undertaken to evaluate the effect of Corchorus Olitorius (Molokhia) soup on the oral absorption of ciprofloxacin from solid dosage forms in rabbits. A single dose of ciprofloxacin tablet (125 mg) was administered to rabbits in a fasted state or with Molokhia soup. Plasma ciprofloxacin concentrations were measured by high-performance liquid chromatography. The results demonstrated a profound effect of Molokhia soup on the bioavailability of ciprofloxacin compared to the fasted state. The intake of Molokhia soup reduced the rate and extent of ciprofloxacin oral bioavailability. The geometric mean (Cmax and AUC) values of ciprofloxacin were significantly lower under fed compared to the fasted states. Administration of ciprofloxacin with Molokhia soup was associated with a delay in the time to reach peak concentration (Tmax) by about half hour. Therefore, co-administration of Molokhia soup with ciprofloxacin may have a potential negative effect on the release and oral absorption of Ciprofloxacin from tablets, This may result in serious decrease in the efficacy of this antibiotic and potential bacterial resistance.These articles may interest you also
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Influence of Corchorus Olitorius (Molokhia) Soup on the In Vivo Absorption of Ciprofloxacin from Immediate Release Tablet in Rabbits
- Asma Radwan
- Naser Shraim
- Josephean Elaraj1
- Malak Jada'a
- Anwar Alheen
- Yasmeen Khanfar
- نضال زعتر
- Mohamad Abdaldaym3
معلومات المقال
2016-05-24
2016-08-23
1 - 6
الكلمات الإفتتاحية
- Corchorus Olitorius
- Food Effect
- Absorption
- Ciprofloxacin
الملخص
This study was undertaken to evaluate the effect of Corchorus Olitorius (Molokhia) soup on the oral absorption of ciprofloxacin from solid dosage forms in rabbits. A single dose of ciprofloxacin tablet (125 mg) was administered to rabbits in a fasted state or with Molokhia soup. Plasma ciprofloxacin concentrations were measured by high-performance liquid chromatography. The results demonstrated a profound effect of Molokhia soup on the bioavailability of ciprofloxacin compared to the fasted state. The intake of Molokhia soup reduced the rate and extent of ciprofloxacin oral bioavailability. The geometric mean (Cmax and AUC) values of ciprofloxacin were significantly lower under fed compared to the fasted states. Administration of ciprofloxacin with Molokhia soup was associated with a delay in the time to reach peak concentration (Tmax) by about half hour. Therefore, co-administration of Molokhia soup with ciprofloxacin may have a potential negative effect on the release and oral absorption of Ciprofloxacin from tablets, This may result in serious decrease in the efficacy of this antibiotic and potential bacterial resistance.These articles may interest you also
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- طيف الامتصاص السيني الدقيق الممتد للتركيبة الزجاجية
- Effects of Daily Supplementation with High Dose Ascorbic Acid on Blood Lead Levels in Broiler Chicken after Intentional Exposure to a Concentrated Source of Lead
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