Formulation, In-Vitro Characterization, And Antifungal Efficacy of Itraconazole Topical Niosomal Gel: Development and Microbiological Evaluation
Authors:
Article info
2024-10-24
2024-12-13
2025-02-26
None - None
Keywords
- Niosomal gel
- Sustained release action
- Antifungal drugs
- Itraconazole
Abstract
Background: Itraconazole is an effective antifungal agent; however, improving its formulation as a topical agent is necessary due to its limited skin penetration and duration of action. The present study aims to improve the efficacy of antifungal treatments for skin infections by developing and studying itraconazole (TCZ) in a prolonged-release niosomal gel (NSM-Gel) formulation. Methods: TCZ‑loaded NSM-Gel was formulated using a thin film hydration technique utilizing various non-ionic surfactants (tweens and spans). The TCZ niosomal gels' different formulae were assessed for pH, entrapment efficiency (EE%), particle size (PS), and polydispersity Index (PDI). Formula (TN4), which was selected as the best formula, was further examined for zeta potential (ZP), in-vitro release, scanning electron microscopy (SEM), physical stability study, and in-vitro antifungal efficacy. Results: the EE% for the developed NSM-Gel is satisfactory (86.41 – 98.44%), PS between 4.12 and 8.17 µm, and PDI between 0.22 and 0.39. The release of TCZ from the NSM-Gel provided an appropriate prolonged release effect. TN4 had an elevated EE% with a delayed release profile (100.00% ± 1.25% after 18hrs). The results revealed the existence of vesicles characterized by a spherical morphology. Physical stability studies of formula (TN4) showed good physical characteristics. Furthermore, TN4 demonstrated superior antifungal activity against Candida albicans, as evidenced by a larger inhibition zone than the commercial product Venzole® gel 1% (2.40 vs. 1.50 cm). Conclusions: This investigation demonstrated the applicability of the NSM-Gel in achieving the expected prolonged release effect for transdermal TCZ administration in healing fungal infections.. (Style=ANU_Abstract)
Formulation, In-Vitro Characterization, And Antifungal Efficacy of Itraconazole Topical Niosomal Gel: Development and Microbiological Evaluation
المؤلفون:
معلومات المقال
2024-10-24
2024-12-13
2025-02-26
None - None
الكلمات الإفتتاحية
- Niosomal gel
- Sustained release action
- Antifungal drugs
- Itraconazole
الملخص
Background: Itraconazole is an effective antifungal agent; however, improving its formulation as a topical agent is necessary due to its limited skin penetration and duration of action. The present study aims to improve the efficacy of antifungal treatments for skin infections by developing and studying itraconazole (TCZ) in a prolonged-release niosomal gel (NSM-Gel) formulation. Methods: TCZ‑loaded NSM-Gel was formulated using a thin film hydration technique utilizing various non-ionic surfactants (tweens and spans). The TCZ niosomal gels' different formulae were assessed for pH, entrapment efficiency (EE%), particle size (PS), and polydispersity Index (PDI). Formula (TN4), which was selected as the best formula, was further examined for zeta potential (ZP), in-vitro release, scanning electron microscopy (SEM), physical stability study, and in-vitro antifungal efficacy. Results: the EE% for the developed NSM-Gel is satisfactory (86.41 – 98.44%), PS between 4.12 and 8.17 µm, and PDI between 0.22 and 0.39. The release of TCZ from the NSM-Gel provided an appropriate prolonged release effect. TN4 had an elevated EE% with a delayed release profile (100.00% ± 1.25% after 18hrs). The results revealed the existence of vesicles characterized by a spherical morphology. Physical stability studies of formula (TN4) showed good physical characteristics. Furthermore, TN4 demonstrated superior antifungal activity against Candida albicans, as evidenced by a larger inhibition zone than the commercial product Venzole® gel 1% (2.40 vs. 1.50 cm). Conclusions: This investigation demonstrated the applicability of the NSM-Gel in achieving the expected prolonged release effect for transdermal TCZ administration in healing fungal infections.. (Style=ANU_Abstract)
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