Palestinian Medical and Pharmaceutical Journal (Pal. Med. Pharm. J.)

Article info

Keywords

• Palestine
• Stages
• Breast Cancer
• Receptors

Abstract

Breast cancer is the leading cause of cancer deaths among females. The aims of this study were to find the most common histological types of the breast cancer in the West Bank/Palestine, their stages, receptor status and the strategies of treatment. This was a retro-spective study that was conducted in two major outpatient clinics for oncology. The data col-lection form was completed by reviewing patients’ medical records. SPSS program was used for data analysis. The study included 400 women; their average of age was 52.16 ± 11.56 years. Ductal carcinoma was the most common 317 (79.3%), then lobular in 60 (15.0%). The highest number of patients 106 (26.5%) were diagnosed in stage three, 100 (25.0%) in stage two, 95 (23.8%) in stage four, and 81 (20.3%) stage one. About potential predictive bi-omarkers, it was found that most patients 353 (88.3%) did not test BRCA1/BRCA2, among the rest who had the test 21 (5.3%) were positive. Regarding Estrogen Receptor (ER), 249 out of 386 (64.5%) for whom the data was available in files had positive test, whereas Progester-one Receptor (PR) test was positive in 225 (58.34%) women out of 385. For HER2 receptor, most patients had negative results 306 (80.3%). The most common type of breast cancer among Palestinian women was invasive ductal carcinoma. Around half of the patients were diagnosed in stage three and four, so better awareness regarding this disease is recommended. A high percentage of patients had positive ER and PR, this makes hormone therapy an im-portant part of treatment.

معلومات المقال

الكلمات الإفتتاحية

• Palestine
• Stages
• Breast Cancer
• Receptors

الملخص

Breast cancer is the leading cause of cancer deaths among females. The aims of this study were to find the most common histological types of the breast cancer in the West Bank/Palestine, their stages, receptor status and the strategies of treatment. This was a retro-spective study that was conducted in two major outpatient clinics for oncology. The data col-lection form was completed by reviewing patients’ medical records. SPSS program was used for data analysis. The study included 400 women; their average of age was 52.16 ± 11.56 years. Ductal carcinoma was the most common 317 (79.3%), then lobular in 60 (15.0%). The highest number of patients 106 (26.5%) were diagnosed in stage three, 100 (25.0%) in stage two, 95 (23.8%) in stage four, and 81 (20.3%) stage one. About potential predictive bi-omarkers, it was found that most patients 353 (88.3%) did not test BRCA1/BRCA2, among the rest who had the test 21 (5.3%) were positive. Regarding Estrogen Receptor (ER), 249 out of 386 (64.5%) for whom the data was available in files had positive test, whereas Progester-one Receptor (PR) test was positive in 225 (58.34%) women out of 385. For HER2 receptor, most patients had negative results 306 (80.3%). The most common type of breast cancer among Palestinian women was invasive ductal carcinoma. Around half of the patients were diagnosed in stage three and four, so better awareness regarding this disease is recommended. A high percentage of patients had positive ER and PR, this makes hormone therapy an im-portant part of treatment.