Palestinian Medical and Pharmaceutical Journal (Pal. Med. Pharm. J.)

Article info

Keywords

• Diabetes Mellitus
• Inflammatory cytokines
• Inflammation
• Growth factors

Abstract

In diabetes mellitus, both inflammatory and growth factors play significant roles in the development and progression of the disease and its associated complications. Diabetics frequently show signs of chronic, low-grade inflammation. Insulin resistance and beta-cell dysfunction are exacerbated by the high levels of pro-inflammatory cytokines prevalent in diabetes, such as TNF-α and IL-6. High levels of the inflammatory marker C-reactive protein are linked to insulin resistance and an increased risk of cardiovascular disease. An upsurge in in diabetes is caused by NF-κB activation. Complications and pathological processes in diabetes may be exacerbated by a dysregulation of growth factors. The angiogenesis-related growth factor vascular endothelial growth factor (VEGF) can be down-regulated in diabetes, resulting to poor tissue perfusion and diabetic retinopathy. Disputes with insulin sensitivity, dysfunctional beta cells, and diabetic complications have all been linked to disruptions in IGF signalling. An imbalance in PDGF signalling can cause aberrant cell proliferation, fibrosis, and delayed wound healing. When NGF levels and signalling are out of whack, it can lead to nerve injury and diabetic neuropathy. Acquiring an awareness of the dynamic relationship between inflammatory and growth factors is essential to unravelling the causes of diabetes and its consequences. Research into new therapeutic strategies for diabetes is actively focusing on targeting these variables and associated signalling pathways. Controlling blood glucose levels, making healthy lifestyle choices, and using effective medications are all essential components of diabetes management.

معلومات المقال

الكلمات الإفتتاحية

• Diabetes Mellitus
• Inflammatory cytokines
• Inflammation
• Growth factors

الملخص

In diabetes mellitus, both inflammatory and growth factors play significant roles in the development and progression of the disease and its associated complications. Diabetics frequently show signs of chronic, low-grade inflammation. Insulin resistance and beta-cell dysfunction are exacerbated by the high levels of pro-inflammatory cytokines prevalent in diabetes, such as TNF-α and IL-6. High levels of the inflammatory marker C-reactive protein are linked to insulin resistance and an increased risk of cardiovascular disease. An upsurge in in diabetes is caused by NF-κB activation. Complications and pathological processes in diabetes may be exacerbated by a dysregulation of growth factors. The angiogenesis-related growth factor vascular endothelial growth factor (VEGF) can be down-regulated in diabetes, resulting to poor tissue perfusion and diabetic retinopathy. Disputes with insulin sensitivity, dysfunctional beta cells, and diabetic complications have all been linked to disruptions in IGF signalling. An imbalance in PDGF signalling can cause aberrant cell proliferation, fibrosis, and delayed wound healing. When NGF levels and signalling are out of whack, it can lead to nerve injury and diabetic neuropathy. Acquiring an awareness of the dynamic relationship between inflammatory and growth factors is essential to unravelling the causes of diabetes and its consequences. Research into new therapeutic strategies for diabetes is actively focusing on targeting these variables and associated signalling pathways. Controlling blood glucose levels, making healthy lifestyle choices, and using effective medications are all essential components of diabetes management.