Palestinian Medical and Pharmaceutical Journal (Pal. Med. Pharm. J.)

Article info

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Keywords

• Hippo signaling pathway
• Zebrafish
• Wnt pathway
• Mef2 pathway
• FGF pathway

Abstract

The purpose of this review is to draw attention to the many ways in which zebrafish (Danio rerio) have been used in biomedical research, particularly in the areas of drug development, regeneration processes, and pathology. Many benefits are associated with zebrafish, such as their tiny size, quick growth, transparency throughout early development, and genetic resemblance to humans. In the field of drug development, they are highly useful for assessing the effectiveness, safety, and adverse effects of drugs, especially in the context of cancer, neurological illnesses, and cardiovascular disease. Brain diseases like addiction and anxiety can be better understood with the help of zebrafish, which are also useful in neurobehavioral research. A wide range of diseases, including those affecting the blood and bones, can be better understood and treated with the use of zebrafish models. These models are also excellent for discovering new drug targets and evaluating the efficacy of possible treatments. Zebrafish can also repair their own fins, hearts, spinal cords, and even their eyes if they become injured. by controlling key signalling cascades like Wnt, Hippo, and FGF, new therapeutic targets have been identified. This renders them priceless for investigations into human tissue injury and organ failure, as well as investigations into mechanisms of regeneration. Researchers still need to think about the limits of zebrafish models, like genetic duplications, physiological and anatomical variances, and the limitations of antibody-based techniques, even though they are useful. Ensuring the applicability of research outputs to human health and illness requires a thorough understanding of these limitations.

معلومات المقال

قيد النشر

الكلمات الإفتتاحية

• Hippo signaling pathway
• Zebrafish
• Wnt pathway
• Mef2 pathway
• FGF pathway

الملخص

The purpose of this review is to draw attention to the many ways in which zebrafish (Danio rerio) have been used in biomedical research, particularly in the areas of drug development, regeneration processes, and pathology. Many benefits are associated with zebrafish, such as their tiny size, quick growth, transparency throughout early development, and genetic resemblance to humans. In the field of drug development, they are highly useful for assessing the effectiveness, safety, and adverse effects of drugs, especially in the context of cancer, neurological illnesses, and cardiovascular disease. Brain diseases like addiction and anxiety can be better understood with the help of zebrafish, which are also useful in neurobehavioral research. A wide range of diseases, including those affecting the blood and bones, can be better understood and treated with the use of zebrafish models. These models are also excellent for discovering new drug targets and evaluating the efficacy of possible treatments. Zebrafish can also repair their own fins, hearts, spinal cords, and even their eyes if they become injured. by controlling key signalling cascades like Wnt, Hippo, and FGF, new therapeutic targets have been identified. This renders them priceless for investigations into human tissue injury and organ failure, as well as investigations into mechanisms of regeneration. Researchers still need to think about the limits of zebrafish models, like genetic duplications, physiological and anatomical variances, and the limitations of antibody-based techniques, even though they are useful. Ensuring the applicability of research outputs to human health and illness requires a thorough understanding of these limitations.