Acute ischemic stroke (AIS) requires prompt intervention to minimize damage, Emergency nurses play an important role in the early management of acute ischemic stroke. Therefore, it is necessary to investigate the knowledge, attitudes, and practice of emergency nurses in Palestine regarding the early management of acute ischemic stroke. Descriptive, cross-sectional study enrolled 270 emergency nurses in 26 hospitals in Palestine between February and April 2024. Knowledge, attitude and practice were evaluated, data collected by self-administrated questionnaire, and inferential analysis were used to analyze the data. This study included 270 nurses, Men slightly outnumber women, representing 51.9% of the participants. The majority of the participants are young adults, with 60.0% in the 20-29 age range, most participants are bachelor's degree holders (71.1%) with less than five years of experience (53.3%). We found the of knowledge level shows that 70.60% of the responses were correct, demonstrating a majority of the nurses have a good understanding of the protocols and procedures in managing acute ischemic stroke. Attitude level shows that 85.40% of the responses were positive attitude. Practice level is shows that 82% of the responses were in good practice. This study shown that majority of the nurses have a good understanding of the protocols and procedures in managing acute ischemic stroke 70.60% of the responses, Positive attitude toward various aspects of AIS management and good practice in the management of AIS.

Acute ischemic stroke (AIS) requires prompt intervention to minimize damage, Emergency nurses play an important role in the early management of acute ischemic stroke. Therefore, it is necessary to investigate the knowledge, attitudes, and practice of emergency nurses in Palestine regarding the early management of acute ischemic stroke. Descriptive, cross-sectional study enrolled 270 emergency nurses in 26 hospitals in Palestine between February and April 2024. Knowledge, attitude and practice were evaluated, data collected by self-administrated questionnaire, and inferential analysis were used to analyze the data. This study included 270 nurses, Men slightly outnumber women, representing 51.9% of the participants. The majority of the participants are young adults, with 60.0% in the 20-29 age range, most participants are bachelor's degree holders (71.1%) with less than five years of experience (53.3%). We found the of knowledge level shows that 70.60% of the responses were correct, demonstrating a majority of the nurses have a good understanding of the protocols and procedures in managing acute ischemic stroke. Attitude level shows that 85.40% of the responses were positive attitude. Practice level is shows that 82% of the responses were in good practice. This study shown that majority of the nurses have a good understanding of the protocols and procedures in managing acute ischemic stroke 70.60% of the responses, Positive attitude toward various aspects of AIS management and good practice in the management of AIS.